![]() ![]() Diphenhydramine is lipophilic and has a relatively large volume of distribution (Vd). For adult patients, the elimination half-life is approximately 9 hours (range: 7 to 12 hours) and approximately 13.5 hours (range: 9 to 18 hours) for elderly patients (range: 9 to 18 hours). ![]() For pediatric patients, the elimination half-life is approximately 5 hours (range: 4 to 7 hours). The elimination half-life of diphenhydramine can vary between age groups. Peak serum levels of diphenhydramine are reached approximately 2 to 3 hours after oral administration. ![]() As a result, individuals are at increased risk of developing potentially fatal arrhythmias, such as torsade de pointes.ĭiphenhydramine pharmacokinetics do not appear to change in the event of intoxication/overdose. This leads to the prolongation of the QT-interval and a flattening of the T-wave. These channels are responsible for the rapid component of the cardiac repolarizing current. ![]() More specifically, diphenhydramine can affect the delayed rectifier potassium ion channels of the heart as it can act as a blocker of potassium channels. ECG changes can be observed, which include the widening of the QRS-complex and tachycardia, possibly caused by the anticholinergic effects of diphenhydramine. For additional information visit Linking to and Using Content from MedlinePlus.Diphenhydramine can also have negative cardiovascular consequences in the setting of toxicity. Any duplication or distribution of the information contained herein is strictly prohibited without authorization. Links to other sites are provided for information only - they do not constitute endorsements of those other sites. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. This site complies with the HONcode standard for trustworthy health information: verify here. Learn more about A.D.A.M.'s editorial policy editorial process and privacy policy. is among the first to achieve this important distinction for online health information and services. follows rigorous standards of quality and accountability. is accredited by URAC, for Health Content Provider (URAC's accreditation program is an independent audit to verify that A.D.A.M. ![]()
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